Phenotypes Associated with This Genotype

Genotype
MGI:3577888

• Allelic Composition: Slc18a2^tm1Edw/Slc18a2^tm1Edw
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic vesicle morphology ( J:96932 )

• synaptic vesicles do not contain dopamine and are empty

abnormal dopaminergic neuron morphology ( J:96932 )

• synaptic vesicles do not contain dopamine and are empty, however biogenesis and cycling of these empty synaptic vesicles is normal, indicating that vesicle filling with dopamine is disturbed

abnormal neurotransmitter secretion ( J:96932 )

• absence of synaptic dopamine release, however no differences in the total number of synaptic vesicles per dopamine terminal or in the density of synaptic vesicles within dopamine terminals

homeostasis/metabolism

decreased dopamine level ( J:96932 )

• dopamine is not stored in synaptic vesicles and is rapidly degraded in the cytoplasm

cellular

abnormal synaptic vesicle morphology ( J:96932 )

• synaptic vesicles do not contain dopamine and are empty