Mouse Genome Informatics
hm
    Angptl6tm1Yo/Angptl6tm1Yo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• approximately 80% of homozygous null mice die at about E13

cardiovascular system
• homozygotes die at around E13 with cardiovascular defects
• poorly formed vitelline vessels in homozygotes that die at E13

embryogenesis
• poorly formed vitelline vessels in homozygotes that die at E13
• poorly formed sack in homozygotes that die at E13

growth/size
• visceral and subcutaneous fat depots were significantly increased at 8 months after birth
• surviving (about 20%) homozygotes become markedly obese even on a normal chow diet

adipose tissue
• visceral and subcutaneous fat depots were significantly increased at 8 months after birth
• white adipose tissue showed increased adipocyte size at 8 months of age

homeostasis/metabolism
• exhibit mild hyperglycemia
• exhibit severe hyperinsulinemia
• leptin concentration was significantly higher than in controls, however no differences in adiponectin or TNF-alpha concentrations
• decrease in rectal temperature
• decrease in whole-body oxygen consumption rates
• large amount of lipid accumulation in liver, skeletal muscle and brown adipose tissue was seen in 8 month old homozygotes
• significant increase in serum cholesterol however no differences in serum triglyceride concentration

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:97552