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Phenotypes Associated with This Genotype
Genotype
MGI:3577766
Allelic
Composition
Angptl6tm1Yo/Angptl6tm1Yo
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Angptl6tm1Yo mutation (0 available); any Angptl6 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 80% of homozygous null mice die at about E13

cardiovascular system
• homozygotes die at around E13 with cardiovascular defects
• poorly formed vitelline vessels in homozygotes that die at E13

embryo
• poorly formed vitelline vessels in homozygotes that die at E13
• poorly formed sack in homozygotes that die at E13

growth/size/body
• surviving (about 20%) homozygotes become markedly obese even on a normal chow diet

adipose tissue
• visceral and subcutaneous fat depots were significantly increased at 8 months after birth
• white adipose tissue showed increased adipocyte size at 8 months of age

homeostasis/metabolism
• exhibit mild hyperglycemia
• exhibit severe hyperinsulinemia
• leptin concentration was significantly higher than in controls, however no differences in adiponectin or TNF-alpha concentrations
• decrease in rectal temperature
• decrease in whole-body oxygen consumption rates
• large amount of lipid accumulation in liver, skeletal muscle and brown adipose tissue was seen in 8 month old homozygotes
• significant increase in serum cholesterol however no differences in serum triglyceride concentration

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:97552


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory