Analysis Tools
growth/size/body
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• reduced body size, even at birth
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• growth rate about 15% slower than normal
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cardiovascular system
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• exhibit significantly reduced carotid artery intimal hyperplasia in response to vascular injury and fewer intimal smooth muscle cells
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• reduced neovascularization of implanted melanoma cells
(J:46091)
• thickness of choroidal neovascular membranes was 31% lower than normal after treatment with krypton lasers
(J:81029)
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• left ventricular diameters did not increase as much after infarction as they did in controls
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• better survival in the first 7 days after myocardial infarction than controls (90% survival as compared to 61%)
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• exhibit impairment of smooth muscle cell migration through a gelatin-coated membrane towards a chemoattractant and in a wound assay
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immune system
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• earlier onset and increased severity of experimental autoimmune encephalomyelitis induced by immunization with myelin oligodendrocyte glycoprotein
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• inflammatory cell infiltration and granulation tissue seen in response to implanted melanoma cells but to a lesser extent than in controls
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• increased T-cell transmigration through the brain endothelium, dependent on the increased expression of Mmp9 seen in lymphocytes
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neoplasm
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• reduced tumor development after implantation of melanoma cells
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nervous system
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• increased T-cell transmigration through the brain endothelium, dependent on the increased expression of Mmp9 seen in lymphocytes
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muscle
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• exhibit impairment of smooth muscle cell migration through a gelatin-coated membrane towards a chemoattractant and in a wound assay
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homeostasis/metabolism
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• better survival in the first 7 days after myocardial infarction than controls (90% survival as compared to 61%)
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