Phenotypes Associated with This Genotype

Genotype
MGI:3576720

• Allelic Composition: Kit^W-v/Kit^W-v
• Genetic Background: involves: CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal ear pigmentation ( J:4062 )

• about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region

• no strial pigmentation in mutants that lack an endocochlear potential

abnormal stria vascularis morphology ( J:4062 )

abnormal stria vascularis vasculature morphology ( J:4062 )

• the capillary network is poorly developed

abnormal strial basal cell morphology ( J:4062 )

• basal cells have no cytoplasmic projections

• basal cells of the stria vascularis do not contain premelanosomes or melanosomes

absent strial intermediate cells ( J:4062 )

• no pigment is present

• 89% lack melanocytes within the stria vascularis

abnormal strial marginal cell morphology ( J:4062 )

• marginal cells have poorly developed basolateral projections

thin stria vascularis ( J:4062 )

• strias are noticeably thinner and are reduced to a two-layered tissue composed only of marginal and basal cells

absent endocochlear potential ( J:4062 )

• 89% of homozygous mutants lack an endocochlear potential

pigmentation

abnormal ear pigmentation ( J:4062 )

• about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region

• no strial pigmentation in mutants that lack an endocochlear potential

abnormal melanocyte morphology ( J:4062 )

• no melanocytes detected in dorsal skin or in hair follicles

absent strial intermediate cells ( J:4062 )

• no pigment is present

• 89% lack melanocytes within the stria vascularis

abnormal melanosome morphology ( J:4062 )

• in mutants that do have endocochlear potential, melanin granules were rarely observed and no melanosomes were detected in marginal or basal cells

cardiovascular system

abnormal stria vascularis vasculature morphology ( J:4062 )

• the capillary network is poorly developed

craniofacial

abnormal ear pigmentation ( J:4062 )

• about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region

• no strial pigmentation in mutants that lack an endocochlear potential

integument

abnormal ear pigmentation ( J:4062 )

• about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region

• no strial pigmentation in mutants that lack an endocochlear potential

growth/size/body

abnormal ear pigmentation ( J:4062 )

• about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region

• no strial pigmentation in mutants that lack an endocochlear potential