Mouse Genome Informatics
cx
    ApcMin/Apc+
Recql4tm1Glu/Recql4tm1Glu

involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• the average maximal diameter of macroadenomas was larger than in double heterozygous controls
• at 120 days of age, exhibited a 2-fold increase in the multiplicity of macroadenomas along the entire GI tract compared to double heterozygous mutant controls, however no difference in the mean or maximal lifespan compared to controls
• mutants always developed tumors in the large intestine, a site that is inconsistently affected in double heterozygous controls

Mouse Models of Human Disease
OMIM IDRef(s)
Rothmund-Thomson Syndrome; RTS 268400 J:97101