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Phenotypes Associated with This Genotype
Genotype
MGI:3575580
Allelic
Composition
ApcMin/Apc+
Recql4tm1Glu/Recql4tm1Glu
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (8 available); any Apc mutation (53 available)
Recql4tm1Glu mutation (0 available); any Recql4 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• the average maximal diameter of macroadenomas was larger than in double heterozygous controls (J:97101)
• the average maximal diameter of macroadenomas was larger than in double heterozygous controls (J:97101)
• at 120 days of age, exhibited a 2-fold increase in the multiplicity of macroadenomas along the entire GI tract compared to double heterozygous mutant controls, however no difference in the mean or maximal lifespan compared to controls (J:97101)
• at 120 days of age, exhibited a 2-fold increase in the multiplicity of macroadenomas along the entire GI tract compared to double heterozygous mutant controls, however no difference in the mean or maximal lifespan compared to controls (J:97101)
• mutants always developed tumors in the large intestine, a site that is inconsistently affected in double heterozygous controls (J:97101)
• mutants always developed tumors in the large intestine, a site that is inconsistently affected in double heterozygous controls (J:97101)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rothmund-Thomson Syndrome; RTS 268400 J:97101


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory