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Phenotypes Associated with This Genotype
Genotype
MGI:3575580
Allelic
Composition
ApcMin/Apc+
Recql4tm1Glu/Recql4tm1Glu
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (8 available); any Apc mutation (85 available)
Recql4tm1Glu mutation (0 available); any Recql4 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• the average maximal diameter of macroadenomas was larger than in double heterozygous controls
• at 120 days of age, exhibited a 2-fold increase in the multiplicity of macroadenomas along the entire GI tract compared to double heterozygous mutant controls, however no difference in the mean or maximal lifespan compared to controls
• mutants always developed tumors in the large intestine, a site that is inconsistently affected in double heterozygous controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Rothmund-Thomson Syndrome; RTS 268400 J:97101


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory