Phenotypes Associated with This Genotype

Genotype
MGI:3575532

• Allelic Composition: Lif^tm1Cgre/Lif^tm1Cgre
• Genetic Background: involves: MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased uterine NK cell number ( J:96965 )

♀ • double the percentage of natural killer cells in the uterus, especially on the antimesometrial side of the uterus, on day 3 of pregnancy

increased eosinophil cell number ( J:96965 )

• higher percentages of eosinophils in the outer stroma of the uterus on day 3 of pregnancy and in the midstroma on day 4, and higher total percentages of eosinophils in the uterus

abnormal macrophage morphology ( J:96965 )

• more than 50% decrease in the number of macrophages in the uterus, especially in the lumen and midstroma, compared to wildtype during pregnancy, especially on day 3 of pregnancy

• distribution of macrophages in the uterus of pregnant mice was disrupted, with few or no macrophages found around the lumen on day 3 of pregnancy and in the myometrium from day 4 of pregnancy onward

immune system

increased uterine NK cell number ( J:96965 )

♀ • double the percentage of natural killer cells in the uterus, especially on the antimesometrial side of the uterus, on day 3 of pregnancy

increased eosinophil cell number ( J:96965 )

• higher percentages of eosinophils in the outer stroma of the uterus on day 3 of pregnancy and in the midstroma on day 4, and higher total percentages of eosinophils in the uterus

abnormal macrophage morphology ( J:96965 )

• more than 50% decrease in the number of macrophages in the uterus, especially in the lumen and midstroma, compared to wildtype during pregnancy, especially on day 3 of pregnancy

• distribution of macrophages in the uterus of pregnant mice was disrupted, with few or no macrophages found around the lumen on day 3 of pregnancy and in the myometrium from day 4 of pregnancy onward

reproductive system

abnormal uterus morphology ( J:96965 )

♀ • decreased numbers of macrophages and increased numbers of natural killer cells and eosinophils in the uterus of pregnant mice, especially on day 3 of pregnancy

increased uterine NK cell number ( J:96965 )

♀ • double the percentage of natural killer cells in the uterus, especially on the antimesometrial side of the uterus, on day 3 of pregnancy

embryo

increased uterine NK cell number ( J:96965 )

♀ • double the percentage of natural killer cells in the uterus, especially on the antimesometrial side of the uterus, on day 3 of pregnancy

endocrine/exocrine glands

increased uterine NK cell number ( J:96965 )

♀ • double the percentage of natural killer cells in the uterus, especially on the antimesometrial side of the uterus, on day 3 of pregnancy