Phenotypes Associated with This Genotype

Genotype
MGI:3575529

• Allelic Composition: Slc19a1^tm1Rsc/Slc19a1⁺
• Genetic Background: involves: 129P2/OlaHsd * SWV/Fnn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:96380 )

• the proliferative zone is enlarged

abnormal colon morphology ( J:96380 )

• colonocyte proliferation is significantly increased

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:96380 )

• the proliferative zone is enlarged

homeostasis/metabolism

abnormal homeostasis ( J:96380 )

• the ratio of S-adenosylmethionine to S-adenosylhomocysteine is decreased in the plasma

increased physiological sensitivity to xenobiotic ( J:96380 )

• 8 weeks after treatment with azoxymethane more aberrant crypts per focus are found in heterozygotes compared to wild-type mice

• 38 weeks after treatment with azoxymethane, inflammatory lesion size is increased however the number of lesions is the same as in wild-type mice