Phenotypes Associated with This Genotype

Genotype
MGI:3575508

• Allelic Composition: Ncam1^tm1Msch/Ncam1^tm1Msch; Tg(Camk2a-cre)1Gsc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:96990 )

N • no overt behavioral abnormalities

N • no deficits in short- and long-term memory in global landmark navigation in the water maze test

nervous system

reduced long-term potentiation ( J:96990 )

• in the CA1 region of the hippocampus

• the deficit in LTP could be rescued by elevation of extracellular Ca<2+> concentrations

• LTP in the CA3 region was normal

absent long-term depression ( J:96990 )

• in the CA1 region of the hippocampus