Ncam1^tm1Msch
Targeted Allele Detail

Summary

• Symbol: Ncam1^tm1Msch
• Name: neural cell adhesion molecule 1; targeted mutation 1, Melitta Schachner
• MGI ID: MGI:3575008
• Synonyms: NCAMff
• Gene: Ncam1 Location: Chr9:49413436-49710225 bp, - strand Genetic Position: Chr9, 26.83 cM
• Alliance: Ncam1^tm1Msch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96990
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeted allele harbors a frt-flanked neo cassette and a floxed exon 5. The neo cassette was subsequently removed by transient expression of Flp-recombinase, resulting in exon 5 flanked by loxP-frt (upstream) and loxP (downstream). Western blot of the brains of homozygous mice shows normal isoform profile and expression level. (J:96990)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncam1 Mutation: 65 strains or lines available

References

• Original: J:96990 Bukalo O, et al., Conditional ablation of the neural cell adhesion molecule reduces precision of spatial learning, long-term potentiation, and depression in the CA1 subfield of mouse hippocampus. J Neurosci. 2004 Feb 18;24(7):1565-77
• All: 10 reference(s)