Phenotypes Associated with This Genotype

Genotype
MGI:3575395

• Allelic Composition: Efna2^tm1Jgf/Efna2^tm1Jgf
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:96025 )

• increased neurogenesis with increased progenitor cell proliferation in the lateral ventricle wall that is paralleled by a similar increase in the integration of neurons in the olfactory bulb

abnormal brain morphology ( J:96025 )

• increased BrdU incorporation and shortened cell cycle in progenitor cells in the lateral ventricle wall of adult brain and increased proliferation of neural progenitor cells in vitro

abnormal olfactory bulb morphology ( J:96025 )

• increased number of newborn neurons in the olfactory bulb, indicating that migration of neurons from the lateral ventricle wall to the olfactory bulb is not impeded

• 44% increase in the number of BrdU-labeled cells that integrate in the adult olfactory bulb, a 15% increase in cell density and 7% increase in cell number in the adult olfactory bulb

cellular

abnormal neuron differentiation ( J:96025 )

• increased neurogenesis with increased progenitor cell proliferation in the lateral ventricle wall that is paralleled by a similar increase in the integration of neurons in the olfactory bulb