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Phenotypes Associated with This Genotype
Genotype
MGI:3574537
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Tg(BCR/ABL1)5Hhi/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (2 available)
Tg(BCR/ABL1)5Hhi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age

neoplasm
• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts

immune system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age
• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age

hematopoietic system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

endocrine/exocrine glands
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:95335


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory