Phenotypes Associated with This Genotype

Genotype
MGI:3529942

• Allelic Composition: Nba10^NZB/Nba10^NZB; X/Yaa
• Genetic Background: C57BL/6-Nba2 Yaa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased monocyte cell number ( J:129409 , J:137656 )

♂ • CD11b⁺ monocyte numbers increase as mice age (J:129409)

♂ • a Gr-1^- monocyte subset is the dominant subset by 10 months of age (J:129409)

♂ • increased susceptibility to monocytosis in males (J:137656)

♂ • 71% monocytosis incidence in males (J:137656)

increased susceptibility to type III hypersensitivity reaction ( J:95829 )

♂ • increased serum gp70 immune complex levels

abnormal immune serum protein physiology ( J:137656 )

♂ • increased production of serum gp70 immune complex in males

increased susceptibility to autoimmune disorder ( J:95829 )

♂

increased autoantibody level ( J:137656 )

♂ • increased anti-ribonucleoprotein production in males

increased anti-nuclear antigen antibody level ( J:95829 )

♂ • increased anti-chromatin and anti-DNA antibodies

increased anti-chromatin antibody level ( J:137656 )

♂

glomerulonephritis ( J:95829 , J:137656 )

♂ • susceptibility to severe glomerulonephritis (J:95829)

♂ • 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)

♂ • increased lupus nephritis score (severity) in males (J:137656)

renal/urinary system

glomerulonephritis ( J:95829 , J:137656 )

♂ • susceptibility to severe glomerulonephritis (J:95829)

♂ • 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)

♂ • increased lupus nephritis score (severity) in males (J:137656)

hematopoietic system

increased monocyte cell number ( J:129409 , J:137656 )

♂ • CD11b⁺ monocyte numbers increase as mice age (J:129409)

♂ • a Gr-1^- monocyte subset is the dominant subset by 10 months of age (J:129409)

♂ • increased susceptibility to monocytosis in males (J:137656)

♂ • 71% monocytosis incidence in males (J:137656)