Phenotypes Associated with This Genotype

Genotype
MGI:3527476

• Allelic Composition: Apoe^tm1Bres/Apoe^tm1Bres; Plau^tm1Mlg/Plau^tm1Mlg
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:44387 )

• at >15 weeks of age, double homozygotes fed an atherogenic diet show only minimal destruction of the atherosclerotic aorta wall relative to Apoe^tm1Bres mice

• in double mutants, the media remain largely intact with continuous elastic membranes and multiple smooth-muscle cell layers; no infiltrating macrophages are detected, except at the base of the intimal plaque

• double mutants show no atherosclerotic aneurysmal dilation or rupture whereas Apoe^tm1Bres mice exhibit a >50% dilation in the diameter of the abdominal aorta

aortic elastic tissue lesions ( J:44387 )

• at >15 weeks of age, double homozygotes fed an atherogenic diet display minimal fragmentation of the internal elastic membranes (EMs) in 10% of plaques; in contrast, Apoe^tm1Bres mice show fragmentation of EMs in 51% of plaques, and perforating transmedial ulceration in 21% of plaques