Phenotypes Associated with This Genotype

Genotype
MGI:3527336

• Allelic Composition: Hsf4^tm1Miv/Hsf4^tm1Miv
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lenticular abnormalities in Hsf4^tm1Miv/Hsf4^tm1Miv mice

vision/eye

abnormal lens morphology ( J:95535 )

• deterioration of the lens with fiber cell material extruded into the vitreous cavity is seen in mice at P10, P28, and 8 weeks of age

abnormal lens fiber morphology ( J:95535 )

• secondary lens fiber cells at E15.5, P1.5, P10, and 4 and 8 week old mutants retain nuclei and other cellular organelles and do not become transparent, unlike wild-type cells

cataract ( J:95535 )

• cataracts develop during the early postnatal period in all homozygotes

microphthalmia ( J:95535 )

• variable degrees of microphthalmia are seen