Hsf4^tm1Miv
Targeted Allele Detail

Summary

• Symbol: Hsf4^tm1Miv
• Name: heat shock transcription factor 4; targeted mutation 1, Nahid F Mivechi
• MGI ID: MGI:3527211
• Synonyms: hsf4^-
• Gene: Hsf4 Location: Chr8:105996433-106002477 bp, + strand Genetic Position: Chr8, 53.04 cM, cytoband D1
• Alliance: Hsf4^tm1Miv page

Lenticular abnormalities in Hsf4^tm1Miv/Hsf4^tm1Miv mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95535
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A floxed EGFP-neo was inserted in-frame after the start codon in exon 1. EGFP expression was demonstrated in developing and adult tissues. Western blot of lens extracts showed the lack of Hsf4 protein in mutants. (J:95535)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hsf4^tm1Miv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsf4 Mutation: 30 strains or lines available

References

• Original: J:95535 Min JN, et al., Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004 Dec;40(4):205-17
• All: 3 reference(s)