About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3526657
Allelic
Composition
Ctsgtm2.1(PML/RARA)Ley/Ctsg+
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsgtm2.1(PML/RARA)Ley mutation (0 available); any Ctsg mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• hepatomegaly with leukemic cell infiltrates is seen in mutants with leukemia
• progressive splenomegaly is seen prior to the onset of leukemia

neoplasm
• heterozygotes develop an abrupt onset, rapidly fatal acute leukemia with a median age of overt onset of 10 months and penetrance of over 90% (J:84230)
• heterozygotes develop acute promyelocytic leukemia with a 150-200 day latency and full penetrance by 350 days of age (J:86458)

hematopoietic system
• progressive splenomegaly is seen prior to the onset of leukemia
• increased numbers of myeloblasts and promyelocytes are seen in mutants with leukemia (J:84230)
• splenic myeloid expansion and aberrant CD34 Gr-1 double positive cells are seen in all mutants (J:86458)
• extramedullary hematopoiesis is seen prior to the onset of leukemia
• seen in mutants with leukemia
• seen in mutants with leukemia
• pronounced leukocytosis is seen in mutants with leukemia

immune system
• progressive splenomegaly is seen prior to the onset of leukemia
• increased numbers of myeloblasts and promyelocytes are seen in mutants with leukemia (J:84230)
• splenic myeloid expansion and aberrant CD34 Gr-1 double positive cells are seen in all mutants (J:86458)
• pronounced leukocytosis is seen in mutants with leukemia

liver/biliary system
• hepatomegaly with leukemic cell infiltrates is seen in mutants with leukemia

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:84230 , J:86458


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/21/2021
MGI 6.17
The Jackson Laboratory