Phenotypes Associated with This Genotype

Genotype
MGI:3525690

• Allelic Composition: Fgfr1^tm1Jpa/Fgfr1^tm1Jpa; Fgfr2^tm1Dor/Fgfr2^tm1Dor; Tg(Hoxb7-cre)5526Cmb/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased renal glomerulus number ( J:95018 )

• reduced numbers of glomeruli in both embryonic and adult kidneys

hydronephrosis ( J:95018 )

• some adult mutants had hydronephrosis occurring unilaterally or bilaterally

small kidney ( J:95018 )

• E13.5 and E16.5 kidneys were smaller than controls

• many adult mutants had small, abnormally shaped kidneys

abnormal ureteric bud morphology ( J:95018 )

• E11.5 ureteric bud explants had abnormally thin, long ureteric stalks and fewer peripheral tips, with a range in phenotype severity

• decrease in the mean number of ureteric bud tips on the surface of E16.5 kidneys

• range of ureteric bud defects at E16.5, including extremely small kidneys with large areas devoid of ureteric tissue