Phenotypes Associated with This Genotype

Genotype
MGI:3525687

• Allelic Composition: Fgfr1^tm1Jpa/Fgfr1⁺; Fgfr2^tm1Dor/Fgfr2^tm1Dor; Tg(Hoxb7-cre)5526Cmb/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased renal glomerulus number ( J:95018 )

• 22% and 24% fewer glomeruli in E11.5 explants and adult kidneys, respectively

abnormal kidney development ( J:95018 )

• defects in cortical stromal mesenchyme patterning, showing aberrantly thickened stroma in subcapsular regions in E13.5 kidneys and regions of massive subcapsular apoptosis in stroma

• absent intercalated stripes of stromal cells in E13.5 kidneys

hydronephrosis ( J:95018 )

• 20% of adult mutants had hydronephrosis occurring unilaterally or bilaterally

small kidney ( J:95018 )

• E13.5 and E16.5 kidneys were smaller than controls

• 80% of adult mutants had small, abnormally shaped kidneys

abnormal ureteric bud morphology ( J:95018 )

• range of ureteric bud defects at E16.5, including extremely small kidneys with large areas devoid of ureteric tissue

• increased apoptotic nuclei in ureteric buds (2-3 apoptotic nuclei compared to none or just one in controls)

• decreased rates of proliferation in ureteric bud tips compared with controls

impaired branching involved in ureteric bud morphogenesis ( J:95018 )

• E11.5 ureteric bud explants exhibited aberrant branching and had abnormally thin, long ureteric stalks and fewer peripheral tips, with a range in phenotype severity

• decrease in the mean number of ureteric bud tips on the surface of E16.5 kidneys (89.5 versus 271 in control)