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Phenotypes Associated with This Genotype
Genotype
MGI:3525456
Allelic
Composition		 Pde4btm1Mct/Pde4b+
Pde4dtm1Mct/Pde4dtm1Mct
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4btm1Mct mutation (3 available); any Pde4b mutation (59 available)
Pde4dtm1Mct mutation (3 available); any Pde4d mutation (184 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil recruitment ( J:94853 )
• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4d mutants or in wild-type

hematopoietic system
impaired neutrophil recruitment ( J:94853 )
• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4d mutants or in wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory