About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3525454
Allelic
Composition		 Pde4btm1Mct/Pde4btm1Mct
Pde4dtm1Mct/Pde4d+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4btm1Mct mutation (3 available); any Pde4b mutation (52 available)
Pde4dtm1Mct mutation (3 available); any Pde4d mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil recruitment ( J:94853 )
• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4b mutants or in wild-type

hematopoietic system
impaired neutrophil recruitment ( J:94853 )
• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4b mutants or in wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory