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Phenotypes Associated with This Genotype
Genotype
MGI:3525267
Allelic
Composition
Itgb4tm2Fgg/Itgb4tm2Fgg
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4tm2Fgg mutation (0 available); any Itgb4 mutation (106 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• cardiovascular development is normal however vascular regrowth is reduced in the retina in response to hypoxia following loss of vessels during a hyperoxic exposure
• tumor angiogenesis is also reduced for multiple lines of injected tumor cells resulting in reduced tumor growth, however in an orthotopic model of mammary carcinogenesis tumor vascularization and growth were not different from wild-type

integument
N
• the skin is not fragile and no defects in epidermal adhesion to the basement membrane are seen


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory