Phenotypes Associated with This Genotype

Genotype
MGI:3525260

• Allelic Composition: Sgk3^tm1Dpea/Sgk3^tm1Dpea
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

abnormal postnatal growth ( J:94650 , J:279604 )

• from 3 to 6 weeks of age mutant males grow slower and mutant females grow slightly faster than wild-type mice of the same sex, however by 7 weeks of age weights had normalized (J:94650)

• although gain weight is slightly slower after birth, body weight is normal at 5-7 months of age (J:279604)

integument

abnormal hair growth ( J:94650 )

sparse hair ( J:94650 )

• sparse hair growth is seen at P10, however the hair becomes progressively thicker similar to wild-type in adults

• proliferation of keratinocytes in the hair bulb is delayed and blunted from P1 to P5

• only 10.9% of the keratinocytes PCNA positive at P4 compared to 57.4% in heterozygotes, this difference is less striking at P5

waved hair ( J:94650 )

abnormal hair shaft morphology ( J:94650 )

• the hair shaft is reduced

abnormal hair follicle development ( J:94650 )

• early hair follicle development is normal, however by P4 the follicles have failed to enlarge and migrate deep into the subcutis

• no abnormalities are seen in the interfollicular epidermis

abnormal hair follicle inner root sheath morphology ( J:94650 )

• the cell layers of the inner root sheath are reduced

abnormal hair follicle orientation ( J:94650 )

• the hair follicles lack the uniform orientation seen in wild-type mice

disorganized outer root sheath cells ( J:94650 )

curly vibrissae ( J:94650 )

behavior/neurological

increased food intake ( J:279604 )

• oral food intake is significantly larger than that in wild-type controls

• however, drinking volume is normal

digestive/alimentary system

increased defecation amount ( J:279604 )

• fecal dry weight is significantly larger than that in wild-type controls

decreased intestinal glucose absorption ( J:279604 )

• glucose-induced current (I_g) in Ussing chamber (a measure of Na⁺ coupled glucose transport) is significantly smaller than that in wild-type jejunal segments

• however, intestinal electrogenic transport of several amino acids (phenylalanine, cysteine, glutamine and proline) is not significantly altered

abnormal feces composition ( J:279604 )

• fecal K⁺ excretion is significantly larger than that in wild-type controls

• however, fecal excretion of Na⁺ and inorganic phosphorus (P_i) is not significantly increased

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:94650 )

N • glucose tolerance and sodium balance and aldesterone induction on a low sodium diet are normal

decreased fasting circulating glucose level ( J:279604 )

• fasting plasma glucose levels are significantly lower than those in wild-type controls

abnormal potassium ion homeostasis ( J:279604 )

• fecal K⁺ excretion is significantly larger than that in wild-type controls