Sgk3^tm1Dpea
Targeted Allele Detail

Summary

• Symbol: Sgk3^tm1Dpea
• Name: serum/glucocorticoid regulated kinase 3; targeted mutation 1, David Pearce
• MGI ID: MGI:3524987
• Synonyms: Sgk3^-
• Gene: Sgk3 Location: Chr1:9868332-9971070 bp, + strand Genetic Position: Chr1, 2.08 cM
• Alliance: Sgk3^tm1Dpea page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94650
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by the deletion of part of exons 9 and 10 containing the ATP-binding site necessary for catalytic activity, and introducing an in-frame stop codon into exon 10. Northern blot of kidney, lung and thymus of mutants showed a lack of mRNA, and Western blot of kidney and liver confirmed a null protein. (J:94650)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgk3 Mutation: 32 strains or lines available

References

• Original: J:94650 McCormick JA, et al., Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol Biol Cell. 2004 Sep;15(9):4278-88
• All: 10 reference(s)