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Phenotypes Associated with This Genotype
Genotype
MGI:3525242
Allelic
Composition
Myoz2tm1Eno/Myoz2tm1Eno
Tg(Myh6-Ppp3ca)37Eno/0
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myoz2tm1Eno mutation (1 available); any Myoz2 mutation (13 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died by 20-28 days of age

cardiovascular system
• 110% increase in myocyte size compared to a 34% increase in mice expressing only the transgene
• showed massive cardiac enlargement that exceeded the hypertrophy induced by the transgene alone
• at 3 weeks of age, 244% increase in heart weight/body weight ratio compared to a 149% increase in mice expressing only the transgene

muscle
• 110% increase in myocyte size compared to a 34% increase in mice expressing only the transgene

growth/size/body
• showed massive cardiac enlargement that exceeded the hypertrophy induced by the transgene alone
• at 3 weeks of age, 244% increase in heart weight/body weight ratio compared to a 149% increase in mice expressing only the transgene


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory