mortality/aging
• died by 20-28 days of age
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cardiovascular system
• 110% increase in myocyte size compared to a 34% increase in mice expressing only the transgene
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• showed massive cardiac enlargement that exceeded the hypertrophy induced by the transgene alone
• at 3 weeks of age, 244% increase in heart weight/body weight ratio compared to a 149% increase in mice expressing only the transgene
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muscle
• 110% increase in myocyte size compared to a 34% increase in mice expressing only the transgene
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growth/size/body
• showed massive cardiac enlargement that exceeded the hypertrophy induced by the transgene alone
• at 3 weeks of age, 244% increase in heart weight/body weight ratio compared to a 149% increase in mice expressing only the transgene
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