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Phenotypes Associated with This Genotype
Genotype
MGI:3525190
Allelic
Composition
Tg(CAG-WRN*K577M)5025Wcl/0
Genetic
Background
involves: C3H * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-WRN*K577M)5025Wcl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• hypersensitivity to 4-nitroquinoline-1-oxide
• reduced replicative potential
• reduced expression of the endogenous WRN protein

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Werner syndrome DOID:5688 OMIM:277700
J:95127


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory