Phenotypes Associated with This Genotype

Genotype
MGI:3525184

• Allelic Composition: Cebpa^tm1Dgt/Cebpa^tm1Dgt; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:94682 )

• mutants treated with poly I:C rarely survive beyond 4-5 weeks of age due to granulocytopenia and sepsis

hematopoietic system

abnormal myelopoiesis ( J:94682 )

• a dramatic loss of Gr-1+ Mac-1+ neutrophils/monocytes is seen in the bone marrow, spleen, and peripheral blood, however T and B cell numbers are normal

failure of myelopoiesis ( J:94682 )

• after poly I:C treatment myelocytes, neutrophils, monocytes, and eosinophils are rarely seen in the bone marrow and the number of immature myeloblasts is increased 32%

• in vitro common myeloid progenitor cells fail to form any mature granulocyte-macrophage, macrophage, or granulocytic colonies

decreased granulocyte number ( J:94682 )

• injection of poly I:C at 2 days after birth resulted in absence of mature granulocytes, however mutants do not develop anemia, thrombocytopenia, or leukemia

immune system

abnormal myelopoiesis ( J:94682 )

• a dramatic loss of Gr-1+ Mac-1+ neutrophils/monocytes is seen in the bone marrow, spleen, and peripheral blood, however T and B cell numbers are normal

failure of myelopoiesis ( J:94682 )

• after poly I:C treatment myelocytes, neutrophils, monocytes, and eosinophils are rarely seen in the bone marrow and the number of immature myeloblasts is increased 32%

• in vitro common myeloid progenitor cells fail to form any mature granulocyte-macrophage, macrophage, or granulocytic colonies

decreased granulocyte number ( J:94682 )

• injection of poly I:C at 2 days after birth resulted in absence of mature granulocytes, however mutants do not develop anemia, thrombocytopenia, or leukemia

sepsis ( J:94682 )