Phenotypes Associated with This Genotype

Genotype
MGI:3525181

• Allelic Composition: Notch1^tm2Rko/Notch1^tm2Rko; Notch2^tm1Rko/Notch2^tm1Rko; Tg(Msx2-cre)5Rem/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:94517 )

• die around P25

endocrine/exocrine glands

absent sebaceous gland ( J:94517 )

• loss of sebaceous glands in embryo-deleted follicles

integument

absent sebaceous gland ( J:94517 )

• loss of sebaceous glands in embryo-deleted follicles

progressive hair loss ( J:94517 )

• regions of bald skin (where Cre was expressed in E9.5 developing follicles) alternating with hair (where Cre was expressed at P1 in follicle cells), however this hair was progressively lost as mice age

absent hair follicle inner root sheath ( J:94517 )

• embryo-deleted follicles contain a melanin-producing core with large, loosely packed cells replacing the inner root sheath

hair follicle degeneration ( J:94517 )

• by P25, P1-deleted follicles are degenerating instead of being in telogen

epidermal hyperplasia ( J:94517 )

scaly skin ( J:94517 )

• regions of scaly skin