Phenotypes Associated with This Genotype

Genotype
MGI:3525155

• Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm; Tg(DO11.10)10Dlo/?
• Genetic Background: involves: 129S2/SvPas * BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

small thymus ( J:50124 )

• size reduced 3 fold

increased double-negative T cell number ( J:50124 )

decreased double-positive T cell number ( J:50124 )

• increased apoptosis of double positive cells

immune system

small thymus ( J:50124 )

• size reduced 3 fold

increased double-negative T cell number ( J:50124 )

decreased double-positive T cell number ( J:50124 )

• increased apoptosis of double positive cells

endocrine/exocrine glands

small thymus ( J:50124 )

• size reduced 3 fold