Phenotypes Associated with This Genotype

Genotype
MGI:3522642

• Allelic Composition: Per2^tm1Ccl/Per2^tm1Ccl
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased salivary gland tumor incidence ( J:79456 )

• relative to wild-type, unirradiated homozygotes display increased sensitivity to neoplastic growth formation in salivary glands

behavior/neurological

shortened circadian behavior period ( J:79456 )

• homozygotes entrain to the LD cycle (12 h light/12 h dark) but display a significantly shorter circadian period in constant darkness (DD)

arrhythmic circadian behavior persistence ( J:79456 )

• homozygotes exhibit loss of persistent circadian rhythmicity within 3 weeks in DD

• most homozygotes do not lose their circadian rhythms immediately upon entry into DD

• upon loss of rhythmicity, a light pulse immediately restores their rhythms, indicating a partially functional clock

cellular

decreased cellular sensitivity to gamma-irradiation ( J:79456 )

• mutant thymocytes exhibit a partial resistance to gamma radiation-induced apoptosis

endocrine/exocrine glands

salivary gland epithelial hyperplasia ( J:79456 )

• at 4 months of age, a number of homozygotes develop salivary gland hyperplasia

• by 7 months of age, most mutants exhibit enlarged salivary glands

increased salivary gland tumor incidence ( J:79456 )

• relative to wild-type, unirradiated homozygotes display increased sensitivity to neoplastic growth formation in salivary glands

digestive/alimentary system

salivary gland epithelial hyperplasia ( J:79456 )

• at 4 months of age, a number of homozygotes develop salivary gland hyperplasia

• by 7 months of age, most mutants exhibit enlarged salivary glands

increased salivary gland tumor incidence ( J:79456 )

• relative to wild-type, unirradiated homozygotes display increased sensitivity to neoplastic growth formation in salivary glands