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Phenotypes Associated with This Genotype
Genotype
MGI:3522324
Allelic
Composition
Apctm2.1Cip/Apctm2.1Cip
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2.1Cip mutation (2 available); any Apc mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• injection with 109 pfu adenovirus cre resulted in 50% mortality within 2 weeks and 95% mortality within 2 months
• lower doses of adenovirus cre resulted in decreased mortality (15% mortality at 2 months with 0.5 x 109 pfu) or no mortality (0.25 x 109 pfu)

neoplasm
• 9 months after injection with 0.5 x 109 pfu adenovirus cre of the 4 out of 6 livers that still contained hepatocytes with the recombined allele developed micronodular preneoplastic foci and/or hepatocellular carcinomas

liver/biliary system
• 7 days after injection with 109 pfu of adenovirus cre the livers of homozygous mutants were 60% larger than heterozygous controls
• hepatocytes containing the recombined allele are selectively lost over time, 9 months after injection with 0.5 x 109 pfu adenovirus cre 6 out of 10 livers still contained hepatocytes with the recombined allele
• 9 months after injection with 0.5 x 109 pfu adenovirus cre of the 4 out of 6 livers that still contained hepatocytes with the recombined allele developed micronodular preneoplastic foci and/or hepatocellular carcinomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:94721


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory