Analysis Tools
behavior/neurological
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• double homozygotes entrain to the LD cycle (12 h light/12 h dark); normal entrainment is caused by the inhibitory ("masking") effect of light on locomotor activity
• when placed in DD, double homozygotes show no circadian rhythms in locomotor activity, clock, or clock-controlled gene expression
• upon loss of rhythmicity, a light pulse fails to reestablish the circadian rhythm, indicating total absence of a functional clock
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