Phenotypes for Nde1 MGI:3514153 MGI Mouse

abnormal neuron differentiation ( J:94756 )

• progressive decrease in cortical progenitor cell proliferation

• altered neuronal cell fate with more neural progenitor cells adapting a neuronal fate between E14.5-E15.5, leading to an increase in deeper layer neurons

• 1.8 fold increase in mitotic cells in the cortical ventricular zone at E15

• altered mitotic orientation (reduction in symmetrical cell division and increase in asymmetrical cell division) and mispositioned mitotic chromosomes in neural progenitor cells

decreased neuronal migration ( J:94756 )

• cerebral cortex neurons at E15 and E17 showed a reduced distance of migration and a more scattered distribution

decreased brain size ( J:94756 )

• brain was 1/3 smaller at 6-8 weeks of age with small size observed from birth throughout adult life

decreased brain weight ( J:94756 )

• the weight of the anterior forebrain was reduced much more than the posterior midbrain and cerebellum

abnormal cerebral cortex morphology ( J:94756 )

• thinner cerebral cortex showing a pronounced thinning in the superficial cortical layers

loss of cortex neurons ( J:94756 )

• severe reduction in later-born superficial cortical neurons (neurons in layers II/III to IV)