Phenotypes for Hand1 Rr133 Tg(Nkx2-5-cre)9Eno MGI:3514077 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Hand1^tm1Eno/Hand1^tm2Eno Rr133^tm1Eno/Rr133^tm1Eno Tg(Nkx2-5-cre)9Eno/0
Genetic Background	either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1^tm1Eno mutation (1 available); any Hand1 mutation (14 available)
Hand1^tm2Eno mutation (0 available); any Hand1 mutation (14 available)
Rr133^tm1Eno mutation (0 available); any Rr133 mutation (0 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:94514 )

• no mutant embryos are found after E9.0

cardiovascular system

abnormal myocardium layer morphology ( J:94514 )

• at E9.0 some segments of the myocardial wall contain cells that resemble mesenchymal cells rather than cardiomyocytes

abnormal heart atrium morphology ( J:94514 )

• at E9.0 only a single atrium is present

abnormal heart ventricle morphology ( J:94514 )

• at E9.0 only a single immature ventricle is present and the lumen of the ventricle is abnormally narrow

trabecula carnea hypoplasia ( J:94514 )

muscle

abnormal myocardium layer morphology ( J:94514 )

• at E9.0 some segments of the myocardial wall contain cells that resemble mesenchymal cells rather than cardiomyocytes

trabecula carnea hypoplasia ( J:94514 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24