Phenotypes Associated with This Genotype

Genotype
MGI:3513684

• Allelic Composition: Jph3^tm1Hta/Jph3^tm1Hta
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:75794 )

N • an open-field test showed no difference in locomotor activity between the mutant and control mice; mutant mice walked normally on the ground, and there was no detectable abnormality in the walking line or step length

impaired coordination ( J:75794 )

• observed in mutant mice in a rotarod test and a rotable bar test; mutant mice showed improved performance with repeated trials in the rotarod test

nervous system

nervous system phenotype ( J:75794 )

N • normal brain histology

N • normal membrane morphology in cerebellar Purkinje cells, in particular, normal junctional membrane structures

N • normal central nervous system electrophysiology; no differences in kinetics of ESPCs or in paired pulse facilitation or depression were detected; some degree of multiple climbing fiber innervation of Purkinje cells was suggested in mutant mice, but the difference was not statistically significant