Phenotypes Associated with This Genotype

Genotype
MGI:3513336

• Allelic Composition: Nid2^{Gt(GST011)Byg}/Nid2^{Gt(GST011)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

osteoarthritis ( J:229684 )

skeleton

osteoarthritis ( J:229684 )

abnormal cartilage morphology ( J:229684 )

• wider zone of calcified cartilage in young mice

• calcium phosphate crystals in the extracellular matrix of cartilage right above the tidemark are increased

abnormal hyaline cartilage morphology ( J:229684 )

• hyaline cartilage of knee joints exhibits signs of early calcification

calcified joint ( J:229684 )

• 9 week old mice exhibit decreased toluidine blue staining in the deeper zones of joint surfaces, indicating calcified cartilage

• hyaline cartilage of knee joints exhibits signs of early calcification

• 24 week old mice exhibit a highly reduced proteoglycan content in the calcified cartilage adjacent to the subchondral bone and in the remaining articular cartilage

cellular

cellular phenotype ( J:78947 )

N • histology and basement membrane formation appeared normal in deficient tissues