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Phenotypes Associated with This Genotype
Genotype
MGI:3513044
Allelic
Composition		 Disp1tm2.1Amc/Disp1tm2Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm2.1Amc mutation (0 available); any Disp1 mutation (61 available)
Disp1tm2Amc mutation (1 available); any Disp1 mutation (61 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
abnormal parietal bone morphology ( J:94270 )
• ossification of the parietal bone is delayed
abnormal nasal pit morphology ( J:94270 )
• abnormally close association of the nasal pits
abnormal facial morphology ( J:94270 )
• facial midline defects are seen

skeleton
abnormal parietal bone morphology ( J:94270 )
• ossification of the parietal bone is delayed

nervous system
abnormal neuron differentiation ( J:94270 )
• the ventral midline cells are an intermediate state between pV3 and floor plate and fewer ventral progenitor cells are seen

respiratory system
abnormal nasal pit morphology ( J:94270 )
• abnormally close association of the nasal pits

cellular
abnormal neuron differentiation ( J:94270 )
• the ventral midline cells are an intermediate state between pV3 and floor plate and fewer ventral progenitor cells are seen

growth/size/body
abnormal facial morphology ( J:94270 )
• facial midline defects are seen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory