Phenotypes Associated with This Genotype

Genotype
MGI:3512435

• Allelic Composition: Txnrd2^tm1.1Marc/Txnrd2^tm1.1Marc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:94136 )

• homozygotes die between E12.5 and E13.5

cardiovascular system

abnormal heart morphology ( J:94136 )

• at E13.0 dysplasia of the cardiac tissues is seen

trabecula carnea hypoplasia ( J:94136 )

• the trabeculae are thinner than normal at E13.0

thin interventricular septum ( J:94136 )

• the ventricular septum is thinner than normal at E13.0

thin ventricular wall ( J:94136 )

abnormal blood flow velocity ( J:94136 )

• bloodstream velocity is decreased at E13.0 in living homozygotes

decreased fetal cardiomyocyte proliferation ( J:94136 )

• cardiomyocyte proliferation is reduced, but no increase in apoptosis is detected

cellular

decreased fetal cardiomyocyte proliferation ( J:94136 )

• cardiomyocyte proliferation is reduced, but no increase in apoptosis is detected

decreased fibroblast proliferation ( J:94136 )

• proliferation of mutant MEFs is significantly slower

hematopoietic system

abnormal definitive hematopoiesis ( J:94136 )

• at E11 and E12.5 increased apoptosis of embryonic blood cells in the liver and reduced size of blood cell colonies formed in a CFU assay are seen

anemia ( J:94136 )

• blood vessels in the yolk sac and embryo contain less blood at E13.5; however, vessel morphology is normal

liver/biliary system

abnormal liver morphology ( J:94136 )

• the liver appears pleiomorphic and spongiform at E11

muscle

trabecula carnea hypoplasia ( J:94136 )

• the trabeculae are thinner than normal at E13.0

decreased fetal cardiomyocyte proliferation ( J:94136 )

• cardiomyocyte proliferation is reduced, but no increase in apoptosis is detected