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Phenotypes Associated with This Genotype
Genotype
MGI:3512279
Allelic
Composition		 Crebbptm1Dli/Crebbp+
Ep300tm1Dli/Ep300+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Dli mutation (1 available); any Crebbp mutation (100 available)
Ep300tm1Dli mutation (1 available); any Ep300 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:47301 )
• unexpectedly, compound heterozygotes die in utero

embryo
decreased embryo size ( J:47301 )
• compound heterozygotes are smaller than control embryos
open neural tube ( J:47301 )
• compound heterozygotes exhibit a severe open neural tube defect similar to that observed in Ep300tm1Dli or Crebbptm1Dli homozygous mutants

growth/size/body
decreased embryo size ( J:47301 )
• compound heterozygotes are smaller than control embryos

nervous system
open neural tube ( J:47301 )
• compound heterozygotes exhibit a severe open neural tube defect similar to that observed in Ep300tm1Dli or Crebbptm1Dli homozygous mutants
exencephaly ( J:47301 )
• compound heterozygotes exhibit extensive exencephaly

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory