Phenotypes Associated with This Genotype

Genotype
MGI:3511504

• Allelic Composition: Tg(Mx1-cre)1Cgn/0; Traf2^tm1Rbr/Traf2^tm1Rbr
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased B cell number ( J:93890 )

• the proportion and total number of B cells were increased in spleen and lymph nodes

abnormal spleen morphology ( J:93890 )

enlarged spleen ( J:93890 )

abnormal spleen marginal zone morphology ( J:93890 )

• the increased number of marginal zone B cells results in an expansion of the marginal zone

increased marginal zone B cell number ( J:93890 )

• the proportion and total number of marginal zone B cells was increased by 3-fold and 5- fold, respectively

immune system

increased B cell number ( J:93890 )

• the proportion and total number of B cells were increased in spleen and lymph nodes

abnormal spleen morphology ( J:93890 )

enlarged spleen ( J:93890 )

abnormal spleen marginal zone morphology ( J:93890 )

• the increased number of marginal zone B cells results in an expansion of the marginal zone

increased marginal zone B cell number ( J:93890 )

• the proportion and total number of marginal zone B cells was increased by 3-fold and 5- fold, respectively

enlarged lymph nodes ( J:93890 )

• the proportion of B cells was doubled, the total B cell numbers were increased 4-fold and B cells were increased in size in the lymph nodes

growth/size/body

enlarged spleen ( J:93890 )