Phenotypes Associated with This Genotype

Genotype
MGI:3511355

• Allelic Composition: Gata3^tm1Jfz/Gata3^tm1Jfz; Tg(Tnfrsf4-cre)1Nik/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:93538 )

increased T-helper 1 cell number ( J:93538 )

• increased numbers of IFN-gamma producing cells in response to Nippostrongylus brasiliensis infection

decreased T-helper 2 cell number ( J:93538 )

• decreased numbers of Il-4 producing cells in response to Nippostrongylus brasiliensis infection

decreased IgE level ( J:93538 )

• very little IgE in the serum in response to Nippostrongylus brasiliensis infection

immune system

abnormal CD4-positive, alpha beta T cell morphology ( J:93538 )

increased T-helper 1 cell number ( J:93538 )

• increased numbers of IFN-gamma producing cells in response to Nippostrongylus brasiliensis infection

decreased T-helper 2 cell number ( J:93538 )

• decreased numbers of Il-4 producing cells in response to Nippostrongylus brasiliensis infection

decreased IgE level ( J:93538 )

• very little IgE in the serum in response to Nippostrongylus brasiliensis infection

increased susceptibility to parasitic infection ( J:93538 )

• failed to expel worms after Nippostrongylus brasiliensis infection