Analysis Tools
immune system
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• when mutant bone marrow cells are transferred to mice lacking surface expression of MHC I, the single positive T cell population in the thymus is composed of small numbers of CD8+ T cells instead of large numbers of CD4+ T cells
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• substantially decreased numbers of CD4+ single positive cells but normal numbers of CD8+ single positive cells
• CD4+ cells found in the lymph nodes had an activated or memory-like phenotype
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• the number of TCRhi CD4 thymocytes is much smaller (0.2 x 106) than in their wild-type counterparts (10.9 x 106)
• the number of CD4 T cells found in the periphery is very small and all have a memory phenotype suggesting they are descendents of an even smaller progenitor pool
• CD4 T cells are virtually absent in the spleen of 1 week old mice, giving further evidence that CD4 T cell population in adults results from expansion of a small progenitor pool
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• in stimulated T cells
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hematopoietic system
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• when mutant bone marrow cells are transferred to mice lacking surface expression of MHC I, the single positive T cell population in the thymus is composed of small numbers of CD8+ T cells instead of large numbers of CD4+ T cells
|
|
• substantially decreased numbers of CD4+ single positive cells but normal numbers of CD8+ single positive cells
• CD4+ cells found in the lymph nodes had an activated or memory-like phenotype
|
|
• the number of TCRhi CD4 thymocytes is much smaller (0.2 x 106) than in their wild-type counterparts (10.9 x 106)
• the number of CD4 T cells found in the periphery is very small and all have a memory phenotype suggesting they are descendents of an even smaller progenitor pool
• CD4 T cells are virtually absent in the spleen of 1 week old mice, giving further evidence that CD4 T cell population in adults results from expansion of a small progenitor pool
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