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Phenotypes Associated with This Genotype
Genotype
MGI:3511195
Allelic
Composition
Zic1/Zic4tm1Kjmi/Zic4+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zic1/Zic4tm1Kjmi mutation (1 available); any Zic4 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• severely affected heterozygotes (15% of all heterozygotes) do not survive past weaning (J:93955)
• severely affected heterozygotes (15% of all heterozygotes) do not survive past weaning (J:93955)

behavior/neurological
• severely affected heterozygotes (15% of all heterozygotes) do not develop a normal righting reflex by P10 (J:93955)
• severely affected heterozygotes (15% of all heterozygotes) do not develop a normal righting reflex by P10 (J:93955)

growth/size/body
• average body weight in severely affected heterozygotes (15% of all heterozygotes) is 45% that of wild-type littermates (J:93955)
• average body weight in severely affected heterozygotes (15% of all heterozygotes) is 45% that of wild-type littermates (J:93955)

nervous system
• in 85% of heterozygotes mild defects are seen in the anterior folia (J:93955)
• in 15% of heterozygotes severe foliar defects are seen (J:93955)
• in 85% of heterozygotes mild defects are seen in the anterior folia (J:93955)
• in 15% of heterozygotes severe foliar defects are seen (J:93955)
• in mildly affected heterozygotes, the vermis is slightly smaller compared to wild-type mice (J:93955)
• in mildly affected heterozygotes, the vermis is slightly smaller compared to wild-type mice (J:93955)
• in severely affected heterozygotes disproportionate vermis hypoplasia is seen (J:93955)
• in severely affected heterozygotes disproportionate vermis hypoplasia is seen (J:93955)

Mouse Models of Human Disease
OMIM ID Ref(s)
Dandy-Walker Syndrome; DWS 220200 J:93955


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory