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Phenotypes Associated with This Genotype
Genotype
MGI:3511019
Allelic
Composition		 Lat2tm1Wz/Lat2tm1Wz
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm1Wz mutation (0 available); any Lat2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:93951 )
• antigen-stimulated granule release is significantly enhanced compared to wild-type
• T, B, dendritic, and natural killer cell development are all normal

hematopoietic system
abnormal mast cell physiology ( J:93951 )
• antigen-stimulated granule release is significantly enhanced compared to wild-type
• T, B, dendritic, and natural killer cell development are all normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory