Phenotypes Associated with This Genotype

Genotype
MGI:3510942

• Allelic Composition: Mospd3^{Gt(PT1-ATG)124Wrst}/Mospd3^{Gt(PT1-ATG)124Wrst}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:93956 )

• about 50% of homozygotes die in the first 24 hours after birth on a C57BL/6 background but not on a mixed C57BL/6 and MF1 background

cardiovascular system

abnormal pulmonary trunk morphology ( J:93956 )

• the caudal origin of the pulmonary trunk is rotated about 90^o relative to the root of the aorta as a result of overgrowth of the conus arteriosus

abnormal ventricle myocardium morphology ( J:93956 )

• 14% reduction in the volume of left ventricular myocardium

papillary muscle hypoplasia ( J:93956 )

• hypoplasia of the right ventricular papillary muscle

ventricular hypoplasia ( J:93956 )

• hypoplasia of the right ventricular papillary muscle results in thinning of the left ventricular myocardium

trabecula carnea hypoplasia ( J:93956 )

• the number and size of the right ventricular trabeculae carnae are reduced

abnormal heart right ventricle outflow tract morphology ( J:93956 )

• overgrowth of the conus arteriosus

decreased heart right ventricle wall thickness ( J:93956 )

• thinning of the right ventricular wall is most pronounced at the cranial border of the parietal wall

• 37% reduction in the volume of the right ventricular free wall

dilated heart right ventricle ( J:93956 )

• 56% increase in volume of the right ventricular chamber

muscle

abnormal ventricle myocardium morphology ( J:93956 )

• 14% reduction in the volume of left ventricular myocardium

trabecula carnea hypoplasia ( J:93956 )

• the number and size of the right ventricular trabeculae carnae are reduced

papillary muscle hypoplasia ( J:93956 )

• hypoplasia of the right ventricular papillary muscle