Phenotypes Associated with This Genotype

Genotype
MGI:3510871

• Allelic Composition: Cebpb^tm1Pfj/Cebpb^tm1Pfj; Tg(Hba-x-v-Ha-ras)TG.ACLed/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:73558 )

• TPA-treated Cebpb^tm1Pfj homozygotes carrying the v-Ha-ras transgene develop 65% fewer Ras-induced papillomas than wild-type, transgene-positive mice

decreased tumor growth/size ( J:73558 )

• notably, the tumor size is reduced by 60% in the Cebpb^tm1Pfj homozygous null background

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:73558 )

• TPA-treated Cebpb^tm1Pfj homozygotes carrying the v-Ha-ras transgene develop 65% fewer Ras-induced papillomas than wild-type, transgene-positive mice