Phenotypes Associated with This Genotype

Genotype
MGI:3510831

• Allelic Composition: Pax3^tm1Mrc/Pax3⁺; Pax7^tm1(cre)Mrc/Pax7⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:93443 )

• because of breathing difficulties few mutants survive beyond 3.5 months of age

neoplasm

neoplasm ( J:93443 )

N • no alveolar rhabdomyosarcomas are detected

craniofacial

abnormal premaxilla morphology ( J:93443 )

• agenesis of the rostral premaxilla is seen

maxilla hypoplasia ( J:93443 )

lacrimal bone hypoplasia ( J:93443 )

• hypoplasia of the lacrimal bone is seen

abnormal nose morphology ( J:93443 )

• a narrowed nose is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

growth/size/body

abnormal nose morphology ( J:93443 )

• a narrowed nose is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

decreased body weight ( J:93443 )

• at 3 weeks of age mutants weigh less than one-third of wild-type littermates

postnatal growth retardation ( J:93443 )

• severe growth retardation is seen by 3 weeks of age

muscle

decreased skeletal muscle fiber diameter ( J:93443 )

• myofiber diameter is reduced

decreased skeletal muscle mass ( J:93443 )

• muscle mass is reduced

decreased satellite cell number ( J:93443 )

• the number of satellite cells is reduced

increased skeletal muscle fiber density ( J:93443 )

• myofiber density is increased

muscle hypoplasia ( J:93443 )

respiratory system

abnormal nose morphology ( J:93443 )

• a narrowed nose is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

skeleton

abnormal premaxilla morphology ( J:93443 )

• agenesis of the rostral premaxilla is seen

maxilla hypoplasia ( J:93443 )

lacrimal bone hypoplasia ( J:93443 )

• hypoplasia of the lacrimal bone is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped