Mouse Genome Informatics
cn
    Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
pigmentation
• mutants closely resemble agouti mice or mice deficient in Pmoc1 or Mcr4

adipose tissue
• body fat is increased 2-fold, a disproportionate increase relative to the increase in body weight

behavior/neurological
• mutants drink 65% more water than wild-type mice
• mutants consume 60% more food than wild-type mice

endocrine/exocrine glands
• the number of beta cells does not increase from 4 to 8 weeks of age unlike in wild-type mice, however by 6 months beta cell numbers are normal as a result of proliferation of cells that escaped cre mediated recombination

growth/size/body
• body fat is increased 2-fold, a disproportionate increase relative to the increase in body weight
• increased body weight is seen after 4 weeks of age with mutants weighing 30% more than wild-type mice at 32 weeks of age
• lean mass and total body fat are increased relative to wild-type mice
• mutants are 10% longer than wild-type mice

homeostasis/metabolism
• fasting and random-fed glucose levels are elevated
• serum insulin is increased 2-fold, however pancreatic insulin levels were decreased more than 2-fold
• increased circulating insulin levels are also seen on a low fat diet
• serum leptin is increased 2-fold
• glucose intolerance is seen on a normal or low fat diet
• glucose clearance rates were decreased about 50% indicating peripheral insulin resistance

integument
• mutants closely resemble agouti mice or mice deficient in Pmoc1 or Mcr4

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:93415