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Phenotypes Associated with This Genotype
Genotype
MGI:3510464
Allelic
Composition
Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3Gt(XAO26)Byg mutation (0 available); any Foxo3 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• females infertile after 12 weeks of age

endocrine/exocrine glands

hematopoietic system
• 1.75-2 times larger than wild-type
• T cell hyperactivity evidenced by increased cytokine production and higher spontaneous NF-kappaB activity

immune system
• T cell hyperactivity evidenced by increased cytokine production and higher spontaneous NF-kappaB activity
• 1.75-2 times larger than wild-type
• 1.75-2 times larger than wild-type

renal/urinary system

reproductive system
• females infertile after 12 weeks of age

respiratory system

digestive/alimentary system

cellular

growth/size/body
• 1.75-2 times larger than wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory