Foxo3^Gt(XAO26)Byg
Gene trapped Allele Detail

Summary

• Symbol: Foxo3^Gt(XAO26)Byg
• Name: forkhead box O3; gene trap XAO26, BayGenomics
• MGI ID: MGI:3510105
• Synonyms: FoxO3a-trap, Foxo3^{Gt(pGT0pfs)1Stlp}, Foxo3^Trap
• Gene: Foxo3 Location: Chr10:42057841-42152691 bp, - strand Genetic Position: Chr10, 22.79 cM
• Alliance: Foxo3^Gt(XAO26)Byg page

Mutation origin

• Mutant Cell Line: XA026
• Germline Transmission: Earliest citation of germline transmission: J:93593
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: The BayGenomics pGT0pfs gene trap vector, containing a splice acceptor sequence upstream of a Beta-geo reporter gene, integrated approximately 5 kb downstream of the first coding exon, resulting in aberrant splicing of the transcript. Western blot analysis did not detect full-length or truncated protein in thymi. (J:93593)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XA026	CC144539 ; (MGI Seq Detail)	5' RACE	Chr10:42150813-42151012 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  12 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo3 Mutation: 48 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:93593 Lin L, et al., Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity. 2004 Aug;21(2):203-13
• All: 12 reference(s)