Phenotypes Associated with This Genotype

Genotype
MGI:3505871

• Allelic Composition: C3^tm1Hrc/C3^tm1Hrc; Lep^ob/Lep^ob
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

polyphagia ( J:80546 )

• polyphagia is seen compared to Lep^ob homozygotes

growth/size/body

decreased body weight ( J:80546 )

• double knock outs have decreased body weight compared to Lep^ob homozygotes

homeostasis/metabolism

abnormal energy expenditure ( J:80546 )

• the average calorie intake/g increase in body weight is greater in double homozygotes compared to Lep^ob homozygotes

abnormal oxygen consumption ( J:80546 )

• oxygen consumption is increased relative to Lep^ob homozygotes and about the same as wild-type mice

abnormal glucose homeostasis ( J:80546 )

decreased circulating insulin level ( J:80546 )

• insulin levels are decreased compared to Lep^ob homozygotes

abnormal lipid homeostasis ( J:80546 )

increased circulating free fatty acids level ( J:80546 )

• postprandial non-esterified fatty acid levels are increased compared to Lep^ob homozygotes and wild-type mice

increased triglyceride level ( J:80546 )

• postprandial triglyceride clearance is delayed in both males and females